Benchmark RadarAI BENCHMARK PROFILE
HEDGEHOG
HEDGEHOG is a six-stage filtration benchmark for evaluating molecular generators on medicinal plausibility, including physicochemical, structural, synthesis, docking, and 3D pose checks, applied to 23 generators and 230,000 molecules.
- Released
- 2026-07-14
- Readiness
- Paper only
- Primary field
- Science & Research
Why it matters
This benchmark exposes that current molecular generators fail to produce compounds that pass all medicinal, synthesis, docking, and 3D filters simultaneously, providing a more realistic evaluation for drug discovery.
Motivation
Generative molecular models can support early drug discovery by proposing new candidate compounds de novo.
Primary resources
Benchmark Radar records only publicly supported details and links back to primary sources for verification.