Benchmark RadarAI BENCHMARK PROFILE
EC-Reason-Bench
EC-Reason-Bench is a training-free diagnostic protocol for LLM enzyme classification, isolating four reasoning levers: output structure, external knowledge, reasoning structure, and robustness, to measure why LLMs fail on EC number prediction.
- Released
- 2026-07-29
- Readiness
- Paper only
- Primary field
- Health & Life Sciences
Why it matters
The protocol reveals that external knowledge is decisive and that reasoning acts as an arbiter among conflicting neighbors, showing that single-number leaderboards obscure the source of accuracy loss. This informs how to design knowledge-integration methods for protein function prediction.
Motivation
Enzyme function prediction is a hierarchical, knowledge-intensive form of protein function classification.
Primary resources
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